Characterization of N-acetylcysteine and ambroxol in anti-oxidant therapy
نویسندگان
چکیده
منابع مشابه
Oxidant scavenger function of ambroxol in vitro: a comparison with N-acetylcysteine.
Highly reactive oxygen metabolites play an important role in inflammatory processes in the lung. Ambroxol (2-amino-3,5-dibromo-N-[trans-4- hydroxycyclohexyl]benzylamine) has been shown to reduce oxidant-mediated cell damage. However, the mechanism of this effect remains unclear. In order to evaluate oxidant scavenger function increasing concentrations of ambroxol (0-10(-3) mol/l) were compared ...
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N-acetylcysteine (NAC) a derivative of amino acid L-cysteine is currently used mainly as an antioxidant. Sulfhydryl group (–SH) within its molecule makes possible to directly scavenge reactive oxygen species (ROS). Indirect antioxidant action of NAC rely on augmentation of the level of reduced glutathione (GSH) – a major body’s antioxidant. Since oxidative stress takes a part in pathogenesis of...
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ژورنال
عنوان ژورنال: Respiratory Medicine
سال: 1998
ISSN: 0954-6111
DOI: 10.1016/s0954-6111(98)90506-6